The human genome comprising three billion base pairs coding for 30,000 to 40,000 genes is constantly attacked by endogenous reactive metabolites, therapeutic drugs and plethora of environmental mutagens that impact its integrity.
Thus it is obvious that the stability of the genome must be under continuous surveillance. This is accomplished by DNA repair mechanisms, which have evolved to remove or to tolerate pre-cytotoxic, pre-mutagenic and pre-clastogenic DNA lesions in an error-free, or in some cases, error-prone way.
Defects in DNA repair give rise to hypersensitivity to DNA-damaging agents, accumulation of mutations in the genome and finally to the development of cancer and various metabolic disorders. The importance of DNA repair is illustrated by DNA repair deficiency and genomic instability syndromes, which are characterized by increased cancer incidence and multiple metabolic alterations.
Up to 130 genes have been identified in humans that are associated with DNA repair. IPMD has developed the innovative nutraceutical solutions to enhance these gene functions so that they can repair the damages and diseases.